Kamagra and all about it

Pharmacodynamics

Kamagra is a drug for the treatment of erectile dysfunction. Sildenafil citrate is a potent and selective inhibitor of cGMP -specific phosphodiesterase type 5 (PDE5). The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the cavernous body during sexual stimulation.

Nitric oxide activates the enzyme guanylate cyclase, which leads to increased levels of cyclic guanosine monophosphate ( cGMP ), relaxation of the smooth muscles of the corpus cavernosum, and increased blood flow in the penis. During sexual arousal, local release of NO under the influence of sildenafil leads to inhibition of PDE5 and an increase in the level of cGMP in the cavernous body, resulting in smooth muscle relaxation and increased blood flow in the cavernous body.

Toxicological characteristics of the drug

Kamagra belongs to practically non-toxic substances. Does not have a local irritating effect. It does not have a teratogenic and embryotoxic effect, does not have an immunotoxic and sensitizing effect.

Compound

One pill Kamagra contains: active substance – sildenafil citrate 70.250/140.500 mg equivalent to sildenafil 50/100 mg; excipients: sodium starch glycolate (type A), povidone (PVPK 30), microcrystalline cellulose, purified talc, magnesium stearate; shell: hypromellose , Instacoat Sol IC-S-3788 (Green)1, Titanium Dioxide (E 171)1 – Contains: Hypromellose (USP*), Polyethylene Glycol (USP*), Talc (USP*), Brilliant Blue E 133 (USP*), quinoline yellow E 104 (USP*), titanium dioxide E 171 (USP*). Description Green, diamond-shaped, film-coated tablets, debossed with “ap” on one side and “KGR 50” on the other, 11.4 to 11.6 mm long, 8.3 to 8.5 mm wide (for a dosage of 50 mg). Green, diamond-shaped, film-coated tablets, debossed with “ap” on one side and “KGR 100” on the other, 14.2 to 14.4 mm long, 10.2 to 10.4 mm wide (for a dosage of 100 mg).

Application

Indications for use Erectile dysfunction, characterized by an inability to achieve or maintain an erection of the penis sufficient for satisfactory intercourse. Buy Kamagra online is effective only in the presence of sexual stimulation. Kamagra should be taken as needed approximately one hour before sexual intercourse. The recommended dose of the Kamagra is 50 mg and is taken before meals. Based on the effectiveness and tolerability of the Kamagra, its dose can be increased to 100 mg or reduced to 25 mg. The maximum recommended dose of the Kamagra is 100 mg. The maximum recommended frequency of taking the Kamagra is 1 time per day.

With mild and moderate degree of renal insufficiency (creatinine clearance 30-80 ml / min), correction of the recommended dose is not required. Due to the fact that in patients with severe renal impairment (creatinine clearance < 30 ml / min), the clearance of sildenafil is reduced, it is necessary in such cases to reduce the dose to 25 mg. In elderly patients, dose adjustment of the Kamagra is not required.

Use in patients taking other medicinal products

When combined with ritonavir , the maximum single dose of the Kamagra super should be 25 mg, not more than 1 time within 48 hours.

When used together with inhibitors of cytochrome P450 3A4 (such as erythromycin, saquinavir, ketoconazole , itraconazole), the initial dose of the Kamagra is 25 mg.

In order to reduce the risk of developing postural arterial hypotension in patients undergoing treatment with alpha – blockers, the condition of patients receiving alpha – blockers should be stabilized. In addition, you should consider using the Kamagra, starting with a dose of 25 mg.

Side effects

Very common – headache

Infrequently – rhinitis – drowsiness – congestion of the paranasal sinuses – dry mouth.

*adverse events recorded only during post-marketing surveillance.

Reporting Suspected Adverse Reactions

Communication of information about suspected adverse reactions identified after registration of the medicinal product is of great importance. This allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals and patients are asked to report any adverse reactions.

Contraindications

Hypersensitivity to any component of the Kamagra – simultaneous use of drugs that are donors of nitric oxide (amyl nitrite) or nitrates in any form – simultaneous use with guanylate cyclase stimulants (riociguat) – severe liver failure – myocardial infarction or stroke suffered in the last 6 months – simultaneous use with inhibitors of the isoenzyme CYP3A4 – simultaneous administration of drugs for the treatment of pulmonary arterial hypertension.

To diagnose erectile dysfunction, determine its possible causes and select the appropriate treatment, it is necessary to collect a complete medical history and conduct a thorough examination.

Buy online Kamagra has not been observed to have any negative effect on the ability to drive a car or other technical means.

Overdose

When taking high doses of the Kamagra, there may be an increase in side effects observed when taking the recommended doses. In case of overdose, general symptomatic and supportive treatment is prescribed.