Sildenafil 20 mg: everything about it and even more

Sildenafil 20 mg (Latin Sildenafil) is the main active ingredient of the original Viagra, the first erectile stimulant for men. This component is able to cause and improve potency. It was created by the world-famous American company Pfizer, which received a patent for implementation in March 1998 after many years of research and development. Today, the first erectile stimulant is available to US residents. In addition to the active effect on the male genital organs, known pills have a positive effect on the female body.

Safety of sexual activity in patients with cardiovascular diseases

Sexual intercourse in most cases is accompanied by physical activity. This makes some people, and especially men suffering from cardiovascular diseases, and their partners, worry about the possibility of developing various complications due to sexual activity sildenafil 20 mg, which can lead to a restriction or complete rejection of it. These fears are reinforced by stories of famous people whose death allegedly took place during sexual intercourse. At the same time, research data show that the risk of cardiovascular complications in patients suffering from cardiac pathology during and immediately after sexual activity, although it exists, is relatively low. For example, the risk of developing myocardial infarction in a healthy 50-year-old man during the year is 1%.

As a result of sexual activity sildenafil 20 mg, this risk increases to 1.01% in a healthy man and to 1.1% in a man with a confirmed diagnosis of coronary artery disease. The absolute risk of developing cardiovascular complications for a healthy man is one chance in a million. This rises to two chances in a million within two hours of intercourse for a healthy man, and to 20 chances in a million for a man with coronary artery disease.

how much sildenafil is too much

Sildenafil 20 mg is contraindicated in patients taking nitrates, in patients with hypotension, in severe hepatic insufficiency (the drug is metabolized by hepatic cytochrome P450 3A4), and in patients with retinopathy pigmentosa.

During intercourse, on average, the maximum heart rate of a man reaches 120-130 beats / min, while systolic blood pressure rises to 150-180 mm Hg. Art. These indicators take place within only 3-5 minutes with an average duration of sexual intercourse from 5 to 15 minutes. The level of stress on the heart is usually expressed in metabolic equivalents (MET). One MET corresponds to the energy requirement expressed as resting oxygen consumption, which is 3.5 ml of oxygen/kg of body weight per minute. In most cases, during sexual activity with a habitual partner, the load is 2-3 METs, with a maximum value of 5-6 METs, depending on the intensity and posture. This corresponds to walking 1.5 km in 20 minutes or climbing 20 steps in 10 seconds. All of the above indicates that sexual activity in habitual conditions and with a familiar partner does not represent a greater danger for both a healthy man and a patient with coronary artery disease than various forms of everyday physical activity.

steroids for sale  Meet sex tinder A report that can meet sex tinder - Subculture meet sex tinder can deal that

In order to standardize the assessment of cardiac risk in men with coronary artery disease who resume sexual activity, several guidelines have been developed. In accordance with these recommendations, all patients are divided into 3 risk groups depending on the number of CHD risk factors they have and / or the severity of cardiovascular pathology. Most patients belong to the low-risk group and do not need additional cardiac examination before resuming sexual activity, which poses no danger to them. Patients in the intermediate risk group require additional cardiac examination, after which they are referred to the low or high risk group. Patients from the high-risk group have severe cardiovascular pathology, accompanied by severe heart failure.

These patients need specialized treatment, after which the question of the danger to them of sexual activity is again considered.

After the introduction of the first PDE-5 inhibitor sildenafil 20 mg into the clinic, reports of the development of cardiovascular complications began to appear. However, later numerous studies have shown that the use of how much sildenafil is too much is not accompanied by clinically significant changes in hemodynamic parameters and cardiac activity at rest and during exercise, both in healthy individuals and in patients with coronary artery disease, as well as in patients receiving antihypertensive drugs. It is important to note that the assessment of hemodynamics and cardiac activity was carried out under loads that occur during sexual intercourse. These data were also confirmed during long-term clinical observation.

Changes in the cavernous electrical activity of the penis during treatment

To evaluate the effect of sildenafil pills on the cavernous electrical activity and hemodynamics of the penis, we conducted our own study. 291 patients with ED of various etiologies aged 21-73 years (mean 59.1 ± 14.7 years) after examination, which included questionnaire survey, pharmacodopplerography (FDG) and electromyography (EMG) of the penis, were divided into age-matched groups, severity, presumed etiology and pathogenesis of ED. The sildenafil 20 mg group included 81 patients who took 25-100 mg of sildenafil 1 hour before sexual intercourse for 6 months. The control examination, which was carried out on a monthly basis, included a survey of IIEF, FDG and EMG of the penis.

steroids for sale  Scientific background and prospects for the use of sildenafil 50 mg in patients with COVID-19

Among patients younger and older than 65 years, the effectiveness of sildenafil 20 mg was 77.6 and 69.2%, respectively. Significantly higher efficacy of tadalafil vs sildenafil, compared with placebo, also occurred in patients with ED of varying severity and etiology.

tadalafil vs sildenafil

The indicator ” erectile function” IIEF in the treatment with sildenafil 20 mg increased by 61.7% (p < 0.05). In FDG after treatment with sildenafil, the peak systolic velocity in the cavernous arteries and the resistance index increased by 16.1% and 34.6%, respectively (p < 0.05). End -diastolic velocity significantly decreased by 27.2% (p < 0.05). In EMG of the penis during treatment with sildenafil, the proportion of normo -reflex EMG curves increased by 43.2%, and the number of arereflectory EMG curves significantly decreased by 73.2% (p < 0.05).

Thus, according to the results of FDG, sildenafil 20 mg affects both arterial and venous blood flow in the penis, which makes it indicated in the first place for vasculogenic ED. EMG showed an improvement in cavernous electrical activity during treatment with sildenafil, apparently due to improved hemodynamics of the penis and oxygenation of the cavernous tissue. In addition, according to the results of the ICEF survey, sildenafil gives a quick and lasting rehabilitation effect.

Conclusion about sildenafil 20 mg

Treatment with sildenafil 20 mg was not only highly effective in patients with depression in terms of improving erectile function, but was also accompanied by a decrease in the severity of depressive symptoms in the first place.

With treatment, there is an improvement in cavernous electrical activity, which justifies its use in neurogenic ED. According to the results of the survey, sildenafil 20 mg gives a quick and lasting therapeutic effect, its effectiveness and safety is assessed as good. Both with short-term use and with long-term use, sildenafil 20 mg does not cause dependence and addiction. The appearance on the market of a new drug sildenafil 20 mg, produced in accordance with quality standards and at the same time affordable, makes the therapeutic arsenal of the urologist- andrologist more diverse and improves the quality of life of more patients with ED.

Tags: , , , , ,