Due to their high efficacy, rapid action and low incidence of side effects, members of the group of phosphodiesterase type 5 inhibitors are the drugs of first choice in the treatment of erectile dysfunction (ED). One of the most widely used drugs in this group currently remains vardenafil levitra. Vardenafil has a number of properties that distinguish it from other drugs in this group: high selectivity and the highest inhibitory activity.
Recently, a new form of the drug has been developed – a tablet. It dissolves in the mouth and should be taken with water. This quality of Vardenafil levitra makes it possible to conveniently take the drug, which provides the desired effect at any time and in any circumstances. Studies have shown that, from a patient’s point of view, ease of use is one of the most important characteristics of the “ideal” treatment for erectile dysfunction.
Currently, Vardenafil levitra reviews is available in a dose of 10 mg. Two large randomized, double-blind, placebo-controlled studies, POTENT I and POTENT II, including a total of more than 700 patients with erectile dysfunction, divided by age into 2 groups, demonstrated high efficacy and good tolerability of Levita in both groups. Thus, Levita is a new and promising form of vardenafil levitra, which is more convenient for use. There is no doubt that due to its high efficiency, good tolerance and ease of use, Vardenafil levitra will take an important place in the arsenal of modern methods of treating erectile dysfunction.
Erectile dysfunction, defined as the inability of a man to achieve and/or maintain an erection sufficient for sexual intercourse, is a medical problem comparable in magnitude to diseases such as arterial hypertension, coronary heart disease, and diabetes mellitus. According to existing data, about 16% of men suffer from erectile dysfunction. At the same time, the number of patients progressively increases with age: in the age group of 20–29 years, the incidence of erectile dysfunction is 8%, and among men aged 70–75 years, it reaches 37%.
Oral drugs of the phosphodiesterase type 5 inhibitor group (iPDE-5) are currently the main treatment for erectile dysfunction. Along with high efficiency, they are easy to use, have a quick effect and rarely cause significant side effects. One of the most widely used PDE-5 iPs today is vardenafil. Vardenafil levitra generic has a number of properties that distinguish it from other drugs in this group. The family of phosphodiesterases includes a large number of different types and pips, and drugs that act predominantly on one type tend to affect others, which can be clinically manifested by various side effects. Vardenafil is the most “selective” PDE-5 i.e. its effect on other forms of this enzyme is less pronounced compared to other representatives of this class of drugs.
In addition, vardenafil levitra is the most “powerful” iPDE. In other words, when comparing the degree of inhibition of enzyme activity with the same amount of different drugs, vardenafil shows the best results. The degree of effect of the drug on PDE-5 is estimated by the value of IC50 – the concentration of the drug, which allows to inhibit the activity of PDE-5 by 50%. The lower the IC50, the higher the inhibitory ability of the drug. Studies have confirmed that vardenafil levitra cost is characterized by the highest binding force to the PDE-5 molecule (IC50) among all drugs of the PDE-5 group. According to the study, PDE-5 activity is listed in descending order: vardenafil; tadalafil sildenafil.
The clinical efficacy of vardenafil in the treatment of erectile dysfunction has been extensively studied in a number of randomized trials. High efficiency and good tolerability of this drug today are not in doubt. It should be noted that vardenafil levitra is also effective in patients with diabetes mellitus, as well as in those who have undergone surgery on the pelvic organs, in particular radical prostatectomy. Erectile dysfunction in these groups is traditionally considered difficult to treat, however, clinical studies have shown good results with the use of vardenafil in such patients.