NEW ASPECTS OF THE USE OF SILDENAFIL 100MG IN THE TREATMENT OF ERECTILE DYSFUNCTION

Currently, there are a large number of effective methods (sildenafil 100mg) of drug treatment of erectile dysfunction (ED). The choice of treatment method is determined by its invasiveness. In case of insufficient effectiveness, a less invasive technique is switched to a more invasive one. Thus, most begin treatment with oral phosphodiesterase type 5 (PDE-5) inhibitors, which fail to respond to other oral agents, intracavernous injections, or vacuum devices. Combination treatment is also possible. With the ineffectiveness of such methods, it is possible to carry out surgical interventions.

SILDENAFIL CITRATE – THE FIRST PDE-5 INHIBITOR

PDE-5 inhibitors are highly effective and safe oral drugs for the treatment of ED and are recommended as first-line agents. The number of patients taking these drugs continues to increase in parallel with the increase in the prevalence of ED.

Sildenafil 100mg citrate was approved for clinical use and became widely known. This moment did not just become the starting point for the existence of another drug on the pharmacological market. It turned out to be the beginning of a new era in the field of sexual medicine, marked by a real breakthrough in the fundamental and clinical fields, as well as in the public perception of sexual pathology.

What is sildenafil became the first effective and safe oral treatment for ED. The story of the discovery of sildenafil 100mg is an example of how an accidental observation can have a huge impact on the course of scientific progress. During clinical trials of a new antianginal drug, the researchers noted that although the drug is not accompanied by a significant clinical improvement in the course of angina pectoris, in many patients it leads to the development of a kind of “side effect”, which consisted in improving erectile function. This observation led to the study of the possibility of using this substance in the treatment of ED.

THE DISCOVERY OF SILDENAFIL

The discovery of sildenafil 100mg, a selective PDE-5 inhibitor, led to numerous fundamental studies showing that this type of enzyme dominates in the cavernous tissue, which ensures the selectivity of the drug.

Clinical trials of sildenafil vs tadalafil have stimulated the creation of new diaries and questionnaires to assess the state of male sexual function. Analysis of the demographics of participants in large-scale clinical trials revealed risk factors for ED, which, in turn, contributed to understanding its pathogenesis.

The appearance of sildenafil 100mg had a huge public outcry. A large number of patients with ED, previously not treated by doctors, have received hope for a cure, and by now, millions of men around the world have returned to a normal sex life thanks to the use of this drug.

DOSING REGIMEN

The dose of the drug is selected by titration, starting with 50 mg, followed by a dose change (either decrease to 25 mg or increase to 100 mg), depending on the effect and tolerability. Sildenafil and alcohol is taken 1 time per day, 1 hour before the intended sexual intercourse. The effect of the drug begins 40-60 minutes after administration and lasts for 3-5 hours, and according to some reports, up to 12 hours. stimulation.

Sildenafil 100mg is contraindicated in patients taking nitrates, in patients with hypotension, in severe hepatic insufficiency (the drug is metabolized by hepatic cytochrome P450 3A4), and in patients with retinopathy pigmentosa.

ANALYSIS OF THE EFFICACY AND TOLERABILITY OF SILDENAFIL

Despite the high efficacy of sildenafil, there remains a certain number of patients in whom taking this drug does not lead to an improvement in erection. In many cases, this is due to improper medication. Patients, especially at the beginning of treatment, should be advised to take sildenafil 100mg on an empty stomach at least 30 minutes before sexual activity.

It is also important to explain to patients that the effect of the drug develops only against the background of adequate sexual arousal and largely depends on it. In many cases, treatment should be started with 100 mg, which will allow a maximum response already at the beginning of treatment and inspire patients with confidence in the success of the treatment. In addition, studies have shown that in some patients the maximum effect of sildenafil is achieved by the 6-8th dose, and therefore in many patients the final assessment of the effectiveness of the drug should be made after several attempts to use it.

A large number of patients with ED, previously not treated by doctors, received hope for a cure, and by now millions of men around the world have returned to a normal sex life thanks to the use of this drug.

SIDE EFFECTS

An important characteristic of any pharmacological drug is its side effects. The most common side effects with silden- fila include headache (7%), facial flushing (7%), dizziness (2%), dyspepsia (1.8%), nasal congestion (1.4%) and visual disturbances, usually in the form of blue staining of objects (1.2%).

In most studies, the frequency of side effects and refusals of treatment as a result of their development was comparable in the groups of patients who received sildenafil and placebo. It should also be noted that the frequency of side effects decreases as the drug is taken.

CONCLUSION

The clinical efficacy of sildenafil 100mg has been evaluated in a large number of studies conducted in many countries around the world. Taking the drug leads to an improvement in erectile function in patients of different ages, regardless of the etiology, severity and duration of ED. The effectiveness of the drug is long-term. Sildenafil affects both arterial and venous blood flow in the penis, making it indicated for vasculogenic ED.